We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cancer-Causing Effects of Orthopaedic Metal Implants in Total Hip Arthroplasty.
- Authors
Sun, Cherry W. Y.; Lau, Lawrence C. M.; Cheung, Jason P. Y.; Choi, Siu-Wai
- Abstract
Simple Summary: Total hip arthroplasty is a well-established orthopaedic procedure, the use of which is on the increase worldwide. Since implants used in arthroplasty are usually made of metals including cobalt, chromium and titanium. These metals have since been classified as potentially carcinogenic and may cause cancers in humans. This retrospective study aimed to investigate whether patients with hip implants have a higher risk of developing any type of cancer. The findings will better inform patients and doctors about the risks and benefits of the type of implants and if patients with implants are at a higher risk of malignancy, then patients with implants may benefit from closer medical monitoring. Background: Metal implants have been preferentially used in THA due to its biocompatibility, mechanical stability and durability. Yet concerns have emerged regarding their potential to release metallic ions, leading to long-term adverse effects, including carcinogenicity. This study aimed to investigate the risk of cancer development in patients with orthopaedic metal implants in total hip arthroplasty (THA). Methods: Patients with THA conducted at a local tertiary implant centre from 2001–2008 were linked to the local cancer registry and followed up to the end of 2023. Standardized incidence ratios (SIRs) for cancer incidence and its confidence interval by Poisson distribution were calculated. Survival analysis was depicted using the Kaplan–Meier method, and the log-rank test was used to assess the differences across groups. Results: The study cohort included 388 patients and 53 cancers diagnosed during follow-up, at least 5 years post THA. All-site cancer risks were increased in patients with THA (SIR: 1.97; 95% CI: 1.48–2.46), validated with chi-square analysis (chi-square = 15.2551, N = 100,388, p < 0.01). A statistically significant increase in multiple site-specific cancers including haematological cancers were identified. Conclusions: Patients with THA were found to have an increased risk for cancer compared to the general population during a mean follow-up of 16 years.
- Subjects
TUMOR risk factors; RISK assessment; POISSON distribution; TOTAL hip replacement; HEMATOLOGIC malignancies; ORTHOPEDIC implants; TERTIARY care; DESCRIPTIVE statistics; CHI-squared test; KAPLAN-Meier estimator; LOG-rank test; METALS; SURVIVAL analysis (Biometry); CONFIDENCE intervals; DISEASE risk factors
- Publication
Cancers, 2024, Vol 16, Issue 7, p1339
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16071339