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- Title
Interaction of the Zika virus with the cytoplasmic dynein-1.
- Authors
Zavala-Vargas, Dan Israel; Visoso-Carbajal, Giovani; Cedillo-Barrón, Leticia; Filisola-Villaseñor, Jessica Georgina; Rosales-Ramirez, Romel; Ludert, Juan E.; Morales-Ríos, Edgar
- Abstract
Zika virus (ZIKV) infection is a major public health threat, making the study of its biology a matter of great importance. By analyzing the viral–host protein interactions, new drug targets may be proposed. In this work, we showed that human cytoplasmic dynein-1 (Dyn) interacts with the envelope protein (E) of ZIKV. Biochemical evidence indicates that the E protein and the dimerization domain of the heavy chain of Dyn binds directly without dynactin or any cargo adaptor. Analysis of this interactions in infected Vero cells by proximity ligation assay suggest that the E–Dyn interaction is dynamic and finely tuned along the replication cycle. Altogether, our results suggest new steps in the replication cycle of the ZIKV for virion transport and indicate a suitable molecular target to modulate infection by ZIKV.
- Subjects
ZIKA virus; ZIKA virus infections; PROTEIN domains; DRUG target; PROTEIN-protein interactions; COATED vesicles
- Publication
Virology Journal, 2023, Vol 20, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-023-01992-6