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- Title
The Perfect Storm: Hemophagocytic Lymphohistiocytosis Complicating Disseminated Yersiniosis.
- Authors
BIDROS, MICHEL; CHIRCH, LISA M.; SANTOS, MARIA T.; TANNENBAUM, SUSAN H.
- Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare but serious medical condition with variable clinical outcome. HLH presents real diagnostic and therapeutic challenges to the treating physician despite the major advances in molecular laboratory testing and the immune-chemotherapeutic interventions. Here we present a unique case of HLH in the setting of hemoglobin H disease provoked by disseminated Yersinia enteroco-litica infection. The hemoglobinopathyled to an iron overload state, which provided an optimal milieu for the siderophilic bacterium, Y. enterocolitica, to disseminate. This overwhelming infection triggered an uncontrolled and dysregulated inflammatory cytokine cascade with resulting clinical sequelae. The patient was treated conservatively without immunosuppressive therapy and recovered quickly. The long-term outcome of such cases needs further definition.
- Subjects
YERSINIA diseases; YERSINIA enterocolitica infections; HEMOGLOBINOPATHY; CYTOKINES
- Publication
Connecticut Medicine, 2014, Vol 78, Issue 3, p143
- ISSN
0010-6178
- Publication type
Case Study