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- Title
Laboratory surveillance of chikungunya in Madhya Pradesh, India (2016-2017).
- Authors
Joshi, Piyush; Yadav, Pragya; Mourya, Devendra; Sahare, Lalit; Ukey, Mahendra; Khedekar, Rameshwar; Patil, Deepak; Barde, Pradip
- Abstract
Background & objectives: Chikungunya (CHIK) is a neglected, re-emerging arboviral disease. Limited information on CHIK-confirmed cases during interepidemic period is available from India. This surveillance study was conducted in Madhya Pradesh (MP), India, during the years 2016-2017, to provide information about CHIK cases. Methods: Blood samples collected from patients suspected having CHIK were tested by immunoglobulin (Ig) IgM ELISA or real time reverse transcription-polymerase chain reaction (rRT-PCR) for the detection of CHIK virus (CHIKV)-specific IgM antibodies or viral RNA, respectively. Partial envelope-1 gene sequencing was done. Clinical and demographic data were collected and analyzed. Results: Of the 4019 samples tested, 494 (12.2%) were found positive for CHIKV infection. The positivity was detected in both rural and urban areas. The mean age of CHIK-positive cases was 33.12±18.25 yr. Headache and joint pain were the most prominent symptoms, 34.6 per cent (171/494) of the CHIK cases required hospitalization and six patients with CHIKV infection died. The East/Central/South African genotype of CHIKV was found to be circulating in the study area. Interpretation & conclusions: Our study recorded a higher CHIK positivity during 2016-2017 in comparison to earlier reports from MP, India. A high proportion of CHIK cases required hospitalization and deaths were also reported, which indicated the severity of the disease in the study area. In-depth molecular analysis of the virus and other risk factors is essential to understand the trends in disease severity.
- Subjects
MADHYA Pradesh (India); INDIA; ARBOVIRUS diseases; VIRAL antibodies; JOINT pain; CHIKUNGUNYA; CITIES &; towns
- Publication
Indian Journal of Medical Research, 2020, Vol 151, Issue 1, p87
- ISSN
0971-5916
- Publication type
Article
- DOI
10.4103/ijmr.IJMR_204_19