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- Title
Pap test accuracy and severity of squamous intraepithelial lesion.
- Authors
Cobucci R. N. O.; Maisonnette M. J. A. S.; Macêdo E. J. S.; Santos Filho F. C.; Rodovalho P. E.F.; Nóbrega M. M.; Gonçalves A. K. S.; Cobucci, Rno; Maisonnette, Mjas; Macêdo, Ejs; Santos Filho, F C; Rodovalho, Pef; Nóbrega, M M; Goncalves, Aks
- Abstract
<bold>Background: </bold>Cytology smears and guided biopsies are the most widely used diagnostic standards for cervical cancer (CC) screening in the developing countries.<bold>Aim: </bold>To evaluate the performance of conventional cytology in estimating the presence and grade of cervical disease against the reference standard of histopathology.<bold>Settings and Design: </bold>After primary screening for CC, directed biopsies were performed and compared with histopathology results.<bold>Materials and Methods: </bold>Papanicolaou (Pap) smears and biopsies from 3194 women in the age group of 14-98 years were included. Cytology results were provided by doctors who performed the cervical biopsies.<bold>Statistical Analysis: </bold>The accuracy of Pap smear was measured by sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) calculated using the statistical analysis program PSPP 0.7.8.<bold>Results: </bold>The sensitivity of conventional cytology (Pap smear) for women with low-grade cervical intraepithelial neoplasia or less serious lesions (CIN1-) was 93% and specificity was 73%. The sensitivity and specificity of cytology for women with high-grade cervical intraepithelial neoplasia or cancer (CIN2+) was 64% and 84%, respectively.<bold>Conclusion: </bold>Cytology is a sufficiently sensitive test for detection of cervical lesions and can be used as a primary testing tool to triage.
- Subjects
PAP test; ACCURACY; CERVICAL cancer diagnosis; MEDICAL screening; HISTOPATHOLOGY; CERVIX uteri disease diagnosis; CERVIX uteri diseases; CROSS-sectional method; DYSPLASIA; DIAGNOSIS
- Publication
Indian Journal of Cancer, 2016, Vol 53, Issue 1, p74
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/0019-509X.180825