We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Thermoresponsive Random Poly(ether urethanes) with Tailorable LCSTs for Anticancer Drug Delivery.
- Authors
Sardon, Haritz; Tan, Jeremy P. K.; Chan, Julian M. W.; Mantione, Daniele; Mecerreyes, David; Hedrick, James L.; Yang, Yi Yan
- Abstract
A new class of thermoresponsive random polyurethanes is successfully synthesized and characterized. Poly(ethylene glycol) diol ( Mn = 1500 Da) and 2,2-dimethylolpropionic acid are reacted with isophorone diisocyanate in the presence of methane sulfonic acid catalyst. It is found that these polyurethanes are thermoresponsive in aqueous media and manifest a lower critical solution temperature (LCST) that can be easily tuned from 30 °C to 70 °C by increasing the poly(ethylene glycol) content. Their sharp LCST transitions make these random polyurethanes ideal candidates for stimuli-responsive drug delivery applications. To that end, the ability of these systems to efficiently sequester doxorubicin (up to 36 wt%) by means of a sonication/dialysis method is successfully demonstrated. Additionally, it is also demonstrated that accelerated doxorubicin release kinetics from the nanoparticles can be attained above the LCST.
- Subjects
URETHANES; ESTERS; ANTINEOPLASTIC agents; ETHYLENE crystals; POLYURETHANES
- Publication
Macromolecular Rapid Communications, 2015, Vol 36, Issue 19, p1761
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.201500247