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- Title
Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid.
- Authors
Zijun Wu; Fangyi Li; Jian Wang
- Abstract
The ubiquitous structure of δ-lactones makes the development of new methods for their enantioselective and stereoselective synthesis an important ongoing challenge. The intermolecular dynamic kinetic resolution (DKR) of β-halo-α-ketoesters cooperatively catalyzed by an N-heterocyclic carbene and a Lewis acid generates two contiguous stereocenters with remarkable diastereoselectivity through an oxidation/ lactonization sequence.
- Subjects
CARBENES; CARBON compounds spectra; LACTONES; STEREOSELECTIVE reactions; LEWIS acids; HETEROCYCLIC compounds synthesis; ENANTIOSELECTIVE catalysis; OXIDATIVE addition; INTRAMOLECULAR forces
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 5, p1649
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201410030