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- Title
Regulated Polyion Complex Vesicles for Efficient Photothermal Therapy.
- Authors
Zhou, Wenjuan; Ding, Peng; Zhang, Chenglin; Wu, Bohang; Guo, Xuhong; Cohen Stuart, Martien A.; Zhou, Xuhui; Wang, Junyou
- Abstract
Polyion complex (PIC) vesicles have attracted considerable attention as soft yet functional delivery vehicles. However, most of the PIC vesicles suffer from insufficient stability and functionality which hinder their applications. Herein, a new type of PIC vesicles obtained by co‐assembly of neutral‐cationic diblock copolymers with a supramolecular coordination polyelectrolyte is reported. The latter exhibits tunable structures and properties that endows regulated stability and functionalities of the vesicles. With lanthanide‐based coordination polymers, PIC vesicles are constructed with not only enhanced stability against salt, but also tunable fluorescent or magnetic properties associated with particular Ln3+ ions. Moreover, the vesicle lumen is applied to load PEGlated indocyanine green as a model photothermal transduction agent. The designed vesicles finally display high stability, good biocompatibility, and efficient photothermal conversion, and therefore behave well for thermal ablation of both tumor cells and tumor in mice. The well‐regulated stability and functions of the PIC vesicles are assigned the adaptive structure and properties of the supramolecular coordination polyelectrolytes, which hardly be achieved with conventional covalent polyelectrolytes. This study therefore demonstrates a facile strategy to regulate the stability and function of PIC vesicles, and shall be inspirational for developing novel vesicular materials for potential biomedical applications.
- Subjects
POLYIONS; SMART structures; PHOTOTHERMAL conversion; POLYELECTROLYTES; INDOCYANINE green; COORDINATION polymers; DIBLOCK copolymers
- Publication
Advanced Functional Materials, 2022, Vol 32, Issue 17, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202108729