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- Title
A New Phenolic Glycoside with α-Glucosidase Inhibitory Activity from Viburnum cylindricum Leaves.
- Authors
Zhang, Xiao-Hui; Chen, Jia; Tang, Yi-Yuan; Zhao, Zi-Yang; Shao, Jian-Hua; Zhao, Chun-Chao
- Abstract
One new phenolic glycoside (1) and two known stereoisomers (2 and 3) were isolated from the methanol extract of Viburnum cylindricum leaves. Their structures were determined as (7R,8S)-guaiacylglycerol 9-O-β-D-glucopyranoside (1), (7S,8R)-guaiacylglycerol 9-O-β-D-glucopyranoside (2), and (7R,8R)-guaiacylglycerol 9-O-β-D-glucopyranoside (3), respectively, by spectroscopic data (1D, 2D NMR, HR-ESI-MS, and ORD) and chemical methods. In addition, compound 1 showed potential α-glucosidase inhibitory activity with the IC50 value of 10.73 μM in comparison with the positive control acarbose (IC50 = 18.84 μM).
- Subjects
VIBURNUM; GLUCOSIDASES; GLYCOSIDES; STEREOISOMERS; ACARBOSE; METHANOL
- Publication
Chemistry of Natural Compounds, 2023, Vol 59, Issue 2, p275
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-023-03975-z