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- Title
The role of the glycome in symbiotic host-microbe interactions.
- Authors
Aminov, Rustam; Aminova, Leila
- Abstract
Glycosylation plays a crucial role in many aspects of cell biology, including cellular and organismal integrity, structure-and-function of many glycosylated molecules in the cell, signal transduction, development, cancer, and in a number of diseases. Besides, at the inter-organismal level of interaction, a variety of glycosylated molecules are involved in the host-microbiota recognition and initiation of downstream signalling cascades depending on the outcomes of the glycome-mediated ascertainment. The role of glycosylation in host-microbe interactions is better elaborated within the context of virulence and pathogenicity in bacterial infection processes but the symbiotic host-microbe relationships also involve substantive glycome-mediated interactions. The works in the latter field have been reviewed to a much lesser extent, and the main aim of this mini-review is to compensate for this deficiency and summarise the role of glycomics in host-microbe symbiotic interactions.
- Subjects
CELLULAR signal transduction; CYTOLOGY; BACTERIAL diseases; GLYCOSYLATION; GLYCOMICS
- Publication
Glycobiology, 2023, Vol 33, Issue 12, p1106
- ISSN
0959-6658
- Publication type
Article
- DOI
10.1093/glycob/cwad073