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- Title
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
- Authors
Song Zhao; Yi-Chinn Weng; Shyng-Shiou F. Yuan; Yi-Tzu Lin; Hao-Chi Hsu; Suh-Chin J. Lin; Gerbino, Elvira; Mei-hua Song; Zdzienicka, Maigorzata Z.; Gatti, Richard A.; Shay, Jerry W.; Ziv, Yael; Shiloh, Yosef; Lee, Eva Y.-H. P.
- Abstract
Discusses a functional link between ataxia-telangiectasia (A-T) and Nijmegen breakage syndrome (NBS) gene products. Susceptibility of A-T and NBS to cancer and similar cellular phenotypes; Mutation of NBS1 in patients with Nijmegen breakage syndrome and the formation of a complex with DNA repair proteins; Various testing methods used, including immunoblotting and immunoprecipitation.
- Subjects
ATAXIA telangiectasia; CHROMOSOME abnormalities; GENETIC mutation; IMMUNOBLOTTING; SCIENCE
- Publication
Nature, 2000, Vol 405, Issue 6785, p473
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35013083