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- Title
تأثیر تمرین هوازی و کپسایسین بر بیان ژنهای لیپوژنیکSREBP-1c و FASN بافت کبدی موشهای صحرایی چاق.
- Authors
فاطمه قریشی; سقا فرج تبار بهرس امیر تقی پور; معصومه حبیبیان
- Abstract
Introduction: Consuming a high-fat diet causes obesity, which is one of the hallmarks of metabolic syndrome. The present study aimed to assess the effect of aerobic training and capsaicin supplementation on the expression of lipogenic genes SREBP-1c and FASN in the liver tissue of obese rats Material & Methods: For this experimental research, 40 eight-week-old male Wistar rats weighing 181.5±2.3 grams were selected as samples. Thereafter, eight rats were fed a normal diet (ND), and 32 rats were fed a high-fat diet (HFD) and randomly assigned to five groups: normal diet, high-fat diet, high-fat diet-training, high-fat dietcapsaicin, and high-fat diet-training-capsaicin. The exercise groups performed an incremental aerobic exercise program (15-25 m/min, 30-60 min/day, five days/week) on a treadmill for eight weeks. Capsaicin (4 mg/kg/day) was taken orally by gavage once a day. Results: Induction of obesity was associated with increased expression of SREBP-1C (P=0.001) and FASN (P=0.001). It was also revealed that aerobic exercise with capsaicin supplementation significantly decreased SREBP-1C and FASN gene expression in the experimental groups compared to the obese group. Finally, this reduction trend was significant in the combined group compared to the supplement group. Discussion & Conclusion: It is possible that the use of capsaicin, along with aerobic physical activity, is an effective strategy to neutralize the markers of hepatic lipogenesis.
- Subjects
LIPID metabolism; THERAPEUTIC use of capsaicin; PROTEIN metabolism; PREVENTION of obesity; TISSUES; EXERCISE therapy; DIETARY fats; GENE expression; RATS; EXPERIMENTAL design; AEROBIC exercises; ANIMAL experimentation; TREADMILLS; LIVER; DIETARY supplements
- Publication
Journal of Ilam University of Medical Sciences, 2024, Vol 32, Issue 2, p44
- ISSN
1563-4728
- Publication type
Article