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- Title
Formaldehitin Sıçan Testislerine Zararı Üzerine Üzüm Çekirdeği Ekstraktının (Vitis vinifera) Koruyucu Etkisi.
- Authors
AŞIK, Gülşah; CAN, Mehmet; ÖZCAN, Emrah
- Abstract
Objective: The aim of this study is to investigate the toxic effects of formaldehyde on testicular tissue and the protective effect of grape seed extract against these toxic effects at biochemical and histopathological levels. Materials and Methods: For this purpose, 21 male Wistar-Albino rats were divided in to three groups. First group rats were used as control. Second group rats were injected intraperitoneal every other day with formaldehyde. Thirth group rats were administered grape seed extract with intragastic injection of formaldehyde. After thirty days, all rats were killed by decapitation after blood samples were taken. The testes of rats were removed and dissected from the surrounding tissue. The activites of superoxide dismutase (SOD), total antioxidante serume (TAS), testosterone and malondialdehyde (MDA) were determined in the some of testicular tissue specimens. The remaining testicular tissue specimens were used for histopathological examination. Results: The activities of SOD and TAS were examined in second group; they were not significantly decreased. It was seen decrease of testosterone degrees in rats administered grape seed extract with exposure of formaldehyde compared to control group. Furthermore, histopathological damages caused by formaldehyde were restored in this group. Conclusion: Formaldehyde exposure caused to harmful effects in testes tissue and grape seed extract have protective effects to these damages.
- Subjects
TESTIS; BIOCHEMISTRY; GRAPE seed extract; FORMALDEHYDE; ANIMAL experimentation; TESTOSTERONE; INTRAPERITONEAL injections; SUPEROXIDE dismutase; ANTIOXIDANTS; RATS; MALONDIALDEHYDE; COMPARATIVE studies; TISSUES
- Publication
Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi, 2022, Vol 11, Issue 3, p487
- ISSN
2146-9601
- Publication type
Article
- DOI
10.53424/balikesirsbd.761145