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- Title
Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults.
- Authors
Hermsdorff, Helen; Volp, Ana; Puchau, Blanca; Barbosa, Kiriaque; Zulet, M.; Bressan, Josefina; Martínez, J.
- Abstract
Objective: This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults. Methods: Measurements included body composition, lifestyle features, blood biochemical and selected inflammatory markers on 317 healthy subjects [122 males/195 females; 22 ± 3 years; 22.1 ± 2.8 kg/m (mean ± SD)]. Results: Women had significantly higher CRP and Cp concentrations than men. No gender difference was noted in C3 concentrations. In a multivariate model of the whole sample, body fat (BF), waist circumference (WC) and the sex × WC interaction term presented the highest R for variance of CRP (11%), C3 (2%), and Cp (12%), respectively. In regression models separated by sex, BF was the adiposity indicator that explained the variability of CRP in men (13%) and women (7%). WC was the only variable significantly associated with C3 concentrations in women (3%). BF presented the highest partial R for Cp in men (8%) and WC in women (16%). Conclusion: Our findings indicate a relevant interaction between gender and body fat distribution on the variance of CRP, C3, and Cp concentrations in apparently healthy young adults.
- Subjects
GENDER; C-reactive protein; CERULOPLASMIN; GENDER differences (Psychology); HUMAN body composition
- Publication
Inflammation Research, 2012, Vol 61, Issue 5, p427
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-011-0429-z