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- Title
Design and characterisation of a Pluronic-F127-based injectable thermoresponsive intratumoural hydrogel.
- Authors
Tanga, Sandrine; Aucamp, Marique; Ramburrun, Poornima
- Abstract
The intravenous administration of chemotherapeutic agents causes an array of side effects during the treatment course, leading to physical and psychological distress. Additionally, these drugs struggle to permeate deep within the tumorous tissue cells which limits their efficacy. Herein, an intratumoral thermoresponsive hydrogel containing Pluronic™ F127 (PF-127) was designed to improve the targeted delivery of oncology drugs to cancer cells. Natural polymers, chitosan (CH) and k-carrageenan (kCRG), were employed to enhance the rheological, mechanical and erosion properties of the hydrogel system. The hydrogel maintained a liquid state at 4 °C and transitioned to a gel at 31 °C, with adequate mechanical and erosion properties. The results of this study indicate that CH/kCRG/PF-127/LIM shows potential as an injectable thermosensitive hydrogel system for administering drugs within solid tumours.
- Subjects
HYDROGELS; BIOPOLYMERS; INTRAVENOUS therapy; PSYCHOLOGICAL distress
- Publication
SA Pharmaceutical Journal Incorporating Pharmacy Management, 2023, Vol 90, Issue 1, p41
- ISSN
2221-5875
- Publication type
Article