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- Title
Minimal activation of memory CD8<sup>+</sup> T cell by tissue-derived dendritic cells favors the stimulation of naive CD8<sup>+</sup> T cells.
- Authors
Belz, Gabrielle T; Bedoui, Sammy; Kupresanin, Fiona; Carbone, Francis R; Heath, William R
- Abstract
Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 α-chain (CD8α) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8+ 'killer' T cells responded to influenza virus antigens presented by lymph node–resident CD8α+ DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.
- Publication
Nature Immunology, 2007, Vol 8, Issue 10, p1060
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1505