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- Title
Dose Sildenafil Citrate Reduce the Incidence of Emergency Cesarean Section and Fetal Distress During Labor? A Randomized Double-Blinded Clinical Trial.
- Authors
Sharami, Seyedeh Hajar; Milani, Forozan; Kabodmehri, Roya; Naghdipour, Misa; Isaabadi, Azade Mahmoudi; Ghadim-Limudahi, Zahra Haghparast
- Abstract
Background: Fetal distress (FD) is one of the most frequent causes of emergency cesarean section (CS) due to the insufficient uteroplacental blood supply during labor. There is a theory that Sildenafil citrate (SC) may improve the uteroplacental blood supply and decrease fetal hypoxia and FD. Methods: In a randomized double-blinded clinical trial, a total of 208 low-risk subjects who met our stringent inclusion criteria were randomly assigned into two groups: the Sildenafil citrate group (n=104) and the placebo group (n=104). These participants were referred to our referral gynecology and obstetrics department for delivery between July 2022 to September 2022. The SC group received oral SC at a dose of 50 mg every 6 hr, up to a maximum of three times. The final maternal-fetal-neonatal results were recorded and all data were analyzed using SPSS version 23. Results: The mean age of mothers was 28.98±5.6 years and 120 cases were primigravid (57.7%). Out of a total of 208 pregnant subjects, 168 subjects delivered through normal vaginal delivery (80.8%) and 40 cases underwent emergency CS (19.2%). The number of NVD in Sildenafil group was significantly more than placebo group (87.5% vs. 74%) and SC decreased the rate of emergency CS to 87.5% (RR=2.46%, 95%CI 1.19-5.08). Also, SC decreased the rate of FD to 53.8% (RR= 2.83%, 95%CI of 1-8.24). Conclusion: The results showed that SC can effectively decrease the rate of emergency CS and FD during labor.
- Subjects
CESAREAN section; RISK assessment; LABOR complications (Obstetrics); PLACEBOS; DELIVERY (Obstetrics); VAGINA; RESEARCH funding; BLIND experiment; STATISTICAL sampling; HOSPITAL emergency services; RANDOMIZED controlled trials; DESCRIPTIVE statistics; RELATIVE medical risk; GYNECOLOGY; SILDENAFIL; DATA analysis software; CONFIDENCE intervals; FETAL distress; UTERUS; FETAL anoxia; OBSTETRICS; DISEASE risk factors
- Publication
Journal of Reproduction & Infertility, 2024, Vol 25, Issue 1, p46
- ISSN
2228-5482
- Publication type
Article
- DOI
10.18502/jri.v25i1.15198