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- Title
Cronkhite-Canada Syndrome: A Rare Cause of Gastrointestinal Polyposis With Response to Emerging Therapy.
- Authors
Khadarian, Kevork; Pai, Rish; Samadder, Niloy Jewel
- Abstract
A 70-year-old man presented to the clinic with a 6-month history of dysgeusia, followed by chronic, non-bloody diarrhea and 45 lb unintentional weight loss. Esophagogastroduodenoscopy discovered confluent nodularity in the gastric antrum and examined duodenum, but a normal esophagus. Colonoscopy uncovered patches of polypoid nodular mucosa throughout the entire colon. Biopsies of the nodular mucosa were consistent with hamartomatous polyps while biopsies of the intervening, normal-appearing mucosa demonstrated edema with crypt architectural distortion. Other hereditary polyposis syndromes were excluded with genetic testing, confirming a diagnosis of Cronkhite-Canada syndrome. Adalimumab therapy was initiated with clinical improvement after nonresponse to prednisone.
- Subjects
DIARRHEA; WEIGHT loss; BIOPSY; INTESTINAL mucosa; ERYTHEMA; TASTE disorders; EDEMA; AUTOANTIBODIES; INTESTINAL polyps; ADALIMUMAB; ENDOSCOPIC gastrointestinal surgery; COLONOSCOPY; SUBCUTANEOUS injections; SERUM albumin; WEIGHT gain
- Publication
ACG Case Reports Journal, 2024, Vol 11, Issue 4, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000001331