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- Title
Granulomatous Hepatitis Treated With Certolizumab Pegol.
- Authors
Brittan, Kevin; Fiedler, Alexandra; Scholten, Kyle; Songtanin, Busara; Manatsathit, Shane
- Abstract
Idiopathic granulomatous hepatitis is a rare condition characterized by hepatic granulomas with constitutional symptoms such as recurrent fevers, myalgias, and hepatosplenomegaly in the absence of infection or inflammatory disorder. Typical treatment and course of this disease consist of a course of steroids with rapid symptomresolution. However, symptomsmay recur when steroids are tapered. In these circumstances, azathioprine, methotrexate, infliximab, and adalimumab have demonstrated good response. In this case, we present a patientwho developed antidrug antibodies to infliximab and adalimumab and was the first documented case of this disease to be treated with certolizumab pegol. Our case highlights the novel efficacy of certolizumab pegol for idiopathic granulomatous hepatitis and its role in treating idiopathic granulomatous hepatitis with antidrug antibodies.
- Subjects
HEPATITIS diagnosis; STEROID drugs; GRANULOMA; DIGESTIVE system endoscopic surgery; CERTOLIZUMAB pegol; ABDOMINAL pain; COMPUTED tomography; RARE diseases; DRUG therapy; IMMUNOGLOBULINS; FEVER; COLONOSCOPY
- Publication
ACG Case Reports Journal, 2024, Vol 11, Issue 4, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000001310