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- Title
IMPORTANŢA HIPOTIROIDISMULUI ÎN EVOLUŢIA ŞI PROGNOSTICUL OSTEOARTRITEI EXPERIMENTALE LA ŞOBOLAN.
- Authors
Dragomir, Ovidiu; Manea, Luminiţa Pleşca
- Abstract
Thyroid hormones play a major role in the normal development of the young joint structure and in the maintenance of the functionality of the mature joint. The effects of thyroid hormones imbalance over articular structures takes place both trough alterations in the phosphocalcic metabolism and trough modifications of cellular growth and proliferation. In view of this data we conceived a experimental study in order to analyze the influence that lower than normal thyroid hormones levels have over the evolution and outcome of experimental osteoarthritis. The osteoarthritis was induced in three groups of adult Wistar-Bratislava rats by intraarticular injection into the left knee joint of 7 doses of 0,02 ml of carrageenan solution 1% over a period of 24 days The group 0 - control - was obtained by harvesting healthy right knee joints from the group 1 rats. The first group received no treatment, the second group received thyamazol 12.5mg/kg by gavage over a period of 8 weeks, and the third group received thyamazol 12.5mg/kg by gavage over a period of 4 weeks, followed by 4 weeks with no treatment. The severity of osteoarthritis was assessed by analyzing the following factors: joint diameter, maximum extension angle of the joint, and the Mankin score for histological evaluation. We obtained statistically significant alterations of the observed parameters both between the control group and the group with continuous hypothyroidism and between the group with continuous hypothyroidism and the group with corrected hypothyroidism suggesting that hypothyroidism is a factor of aggravation of a already present osteoarthritis and furthermore, correction of hypothyroidism improves the outcome of experimental osteoarthritis.
- Subjects
THYROID hormones; OSTEOARTHRITIS; HYPOTHYROIDISM; ENDEMIC goiter; RHEUMATOID arthritis; GROWTH factors; CELL growth; CELL proliferation; KNEE; LABORATORY rats
- Publication
Clujul Medical, 2010, Vol 83, Issue 2, p250
- ISSN
1222-2119
- Publication type
Article