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- Title
Follow-Up Investigations of Tau Protein and S-100B Levels in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease.
- Authors
Cepek, Lukas; Steinacker, Petra; Mollenhauer, Brit; Wiese, Birgitt; Ciesielczyk, Barbara; Bibl, Mirko; Wiltfang, Jens; Zerr, Inga; Schulz-Schaeffer, Walter; Kretzschmar, Hans A.; Poser, Sigrid; Otto, Markus
- Abstract
Background: S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment. Patients and Methods: We analyzed CSF of 45 patients with CJD and of 45 patients with other neurological diseases for tau protein and S-100B in a follow-up setting. All diagnoses of CJD were later neuropathologically verified. A ratio between tau protein differences and the time between lumbar puncture was calculated. The same was done for S-100B. Results: Tau protein levels of 34 cases were above the cut-off level for CJD (>1,300 pg/ml) in the first CSF sample. In 7 of 11 patients with lower tau levels in the first CSF sample, tau levels rose. The above-mentioned ratio was significantly higher in the CJD group than in the group with other neurological diseases. Similar results were obtained for S-100B. Conclusion: We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. Variations in this pattern were observed in single cases. Copyright © 2005 S. Karger AG, Basel
- Subjects
CREUTZFELDT-Jakob disease; PROTEINS; CEREBROSPINAL fluid; BIOMARKERS; CENTRAL nervous system diseases
- Publication
Dementia & Geriatric Cognitive Disorders, 2005, Vol 19, Issue 5/6, p376
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000084708