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- Title
POST CHRONIC CIGARETTE SMOKE EXPOSURE AND ASSESSMENT OF LEARNING, MEMORY AND ASYMPTOMATIC LEVEL OF PERFORMANCE IN WISTAR RATS.
- Authors
Badamasi, I. M.; Lawal, I. U.
- Abstract
This study is to further assess the effect of cessation of chronic cigarette smoke exposure(CSE) on memory, learning and asymptomatic level of performance(ALOP). The design of the study was a single blind randomized control trial involving exposed and control group of rats. Water-maze assessment of learning, memory and ALOP revealed a progressive decline in the latency-time with each sessions, for all study groups- implying that learning was taking place. The female exposed rats had the most difficulty in learning the task compared to the other study groups. In-addition, ALOP was averagely attained by the 4th and 5th session for the exposed and control groups. Furthermore, memory for these sessions was demonstrated by all study groups, with the female-exposed group depicting the highest level. Hippocampal histology revealed a dichotomy between exposed and control groups. The exposed groups had nuclei condensation-pyknosis and edematous changes. Hence, the observation of both a difficulty in learning and a high level of memorization in the female-exposed group suggest that, this study setting favors the recovery of the apparatuses-especially hippocampus, involved in these function from any deleterious effect of chronic CSE. And that the recovery of the males is faster than those of the females.
- Subjects
CIGARETTE smoke; LEARNING in animals; ANIMAL memory; TASK performance; MEMORIZATION; FEMALES; PSYCHOLOGY
- Publication
Bayero Journal of Pure & Applied Sciences, 2015, Vol 8, Issue 2, p46
- ISSN
2006-6996
- Publication type
Article
- DOI
10.4314/bajopas.v8i2.10