We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Temporal Change of Interleukin-6, C-Reactive Protein, and Skin Temperature after Total Knee Arthroplasty Using Triclosan-Coated Sutures.
- Authors
Lin, Shih-Jie; Chang, Fu-Chun; Huang, Tsan-Wen; Peng, Kuo-Ti; Shih, Hsin Nung; Lee, Mel S.
- Abstract
The risk of surgical site infections (SSIs) after total knee arthroplasty (TKA) can never be eliminated. Antimicrobial sutures containing triclosan have been used to decrease SSIs, but whether triclosan-coated sutures are effective with TKA is unclear. Between 2011 and 2012, 102 patients randomly assigned to a triclosan or a control group were prospectively assessed. The incidence of SSI within 3 months of surgery, length of hospital stay, pain scale, functional scores, wound condition, and serum inflammatory markers during hospitalization and within 3 months postoperatively were compared. At the final follow-up, there were 2 patients with superficial infections (3.9%) in the control group but none in the triclosan group. Lower serum IL-6 was detected in the triclosan group at 4 weeks and 3 months. The local skin temperature of the knees—recorded at 3 months using infrared thermography—was lower in the triclosan group than in the control group. More precise analytical measurements are needed to investigate local and systemic complications, especially in the early subclinical stage. This prospective, randomized, open-label clinical trial is in the public registry: ClinicalTrials.gov (<ext-link>NCT02533492</ext-link>).
- Subjects
TRICLOSAN; C-reactive protein; CHI-squared test; FISHER exact test; LENGTH of stay in hospitals; PATIENT aftercare; INTERLEUKINS; LONGITUDINAL method; ORTHOPEDIC surgery; SURGICAL complications; SURGICAL site infections; SUTURES; TOTAL knee replacement; SKIN temperature; RANDOMIZED controlled trials; CONTROL groups; DISEASE incidence; PATIENT selection; DATA analysis software; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
BioMed Research International, 2018, Vol 2018, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2018/9136208