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- Title
Successful second transplantation with non-myeloablative conditioning using haploidentical donors for young patients after graft failure following double umbilical cord cell transplantation.
- Authors
Huilan Liu; Xingbing Wang; Liangquan Geng; Baolin Tang; Juan Tong; Wen Yao; Zuyi Wang; Zimin Sun
- Abstract
Liu H, Wang X, Geng L, Tang B, Tong J, Yao W, Wang Z, Sun Z. Successful second transplantation with non-myeloablative conditioning using haploidentical donors for young patients after graft failure following double umbilical cord cell transplantation. Pediatr Transplantation 2010: 14:465–470. © 2009 John Wiley & Sons A/S. GF is a common and life-threatening complication of UCBT. Here, we report that successful second transplantation of five patients using G-CSF-mobilized maternal stem cells with non-myeloablative conditioning after GF following double UCBT. The median interval between the two transplants were 38 days. The first transplantation was administered after myeloablative conditioning for hematologic malignancies (n = 3), and rabbit ATG in combination with cyclophosphamide for SAA (n = 2). The second conditioning consisted of Flu and ATG-based non-myeloablative regimen. All five patients acquired quick and sustained engraftment after the second transplant. Treatment-related toxicity was minimal. Three patients developed acute GVHD (>grade II = 1). Three patients developed chronic GVHD (limited = 1, extensive = 2). Severe infectious episodes were significant but manageable. With a median follow-up of 713 days (592–1127), all patients have currently had an event-free survival. These results indicate that a second transplant with non-myeloablative conditioning using mother as the donor for young patient after GF is feasible.
- Subjects
UMBILICAL cord; CELL transplantation; STEM cells; CYCLOPHOSPHAMIDE; HEMATOLOGY
- Publication
Pediatric Transplantation, 2010, Vol 14, Issue 4, p465
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/j.1399-3046.2009.01231.x