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- Title
Hypothermic Oxygenated New Machine Perfusion System in Liver and Kidney Transplantation of Extended Criteria Donors:First Italian Clinical Trial.
- Authors
Ravaioli, Matteo; De Pace, Vanessa; Angeletti, Andrea; Comai, Giorgia; Vasuri, Francesco; Baldassarre, Maurizio; Maroni, Lorenzo; Odaldi, Federica; Fallani, Guido; Caraceni, Paolo; Germinario, Giuliana; Donadei, Chiara; Malvi, Deborah; Del Gaudio, Massimo; Bertuzzo, Valentina Rosa; Siniscalchi, Antonio; Ranieri, Vito Marco; D'Errico, Antonietta; Pasquinelli, Gianandrea; Morelli, Maria Cristina
- Abstract
With the aim to explore innovative tools for organ preservation, especially in marginal organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion (HOPE) in the field of liver (LT) and kidney transplantation (KT) from Extended Criteria Donors (ECD) after brain death. A matched-case analysis of donor and recipient variables was developed: 10 HOPE-ECD livers and kidneys (HOPE-L and HOPE-K) were matched 1:3 with livers and kidneys preserved with static cold storage (SCS-L and SCS-K). HOPE and SCS groups resulted with similar basal characteristics, both for recipients and donors. Cumulative liver and kidney graft dysfunction were 10% (HOPE L-K) vs. 31.7%, in SCS group (p = 0.05). Primary non-function was 3.3% for SCS-L vs. 0% for HOPE-L. No primary non-function was reported in HOPE-K and SCS-K. Median peak aspartate aminotransferase within 7-days post-LT was significantly higher in SCS-L when compared to HOPE-L (637 vs.344 U/L, p = 0.007). Graft survival at 1-year post-transplant was 93.3% for SCS-L vs. 100% of HOPE-L and 90% for SCS-K vs. 100% of HOPE-K. Clinical outcomes support our hypothesis of machine perfusion being a safe and effective system to reduce ischemic preservation injuries in KT and in LT.
- Subjects
LIVER transplantation; KIDNEY transplantation; ORGAN donors; INFUSION therapy equipment
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-62979-9