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- Title
Echinococcus multilocularismetacestode extract triggers human basophils to release interleukin-4.
- Authors
Aumüller, E.; Schramm, G.; Gronow, A.; Brehm, K.; Gibbs, B. F.; Doenhoff, M. J.; Haas, H.
- Abstract
Infections with parasitic helminths are associated with a T helper 2 (Th2) immune response and IgE production. The underlying mechanism, however, is only partially understood. Recently we have isolated a protein from extracts ofSchistosoma mansonieggs that triggers human basophils from non-sensitized donors to release interleukin-4 (IL-4), the key cytokine of a Th2 response. We called this protein IPSE (for IL-4-inducing principle fromSchistosoma mansonieggs). Supposing that IPSE-like IL-4-inducing activities might be a general principle shared among different helminth species, we investigated extracts from the cestodeE. multilocularisfor its effect on human basophils. Our results showed that extracts from metacestodes ofE. multiloculariscause basophil degranulation, as well as the secretion of histamine, IL-4 and IL-13, in a dose-dependent manner. IgE stripping and resensitization of basophils indicated that the mechanism of IL-4 induction requires the presence of IgE on the cells. Since analogous properties have been demonstrated earlier for IPSE, we think thatS. mansoniandE. multilocularismay induce a Th2 response in their hosts via a related mechanism, namely, by the induction of IL-4 release from basophils.
- Subjects
ECHINOCOCCUS; BASOPHILS; INTERLEUKIN-4; IMMUNOGLOBULIN E; PARASITES; IMMUNE response; IMMUNOLOGY; HELMINTHIASIS
- Publication
Parasite Immunology, 2004, Vol 26, Issue 10, p387
- ISSN
0141-9838
- Publication type
Article
- DOI
10.1111/j.0141-9838.2004.00724.x