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- Title
Dissociation of interleukin-4 and interleukin-5 production following treatment for Schistosoma haematobium infection in humans.
- Authors
Scott, Janet T.; Turner, C.michael R.; Mutapi, Francisca; Woolhouse, Mark E.J.; Chandiwana, Steven K.; Mduluza, Takafira; Ndhlovu, Patricia D.; Hagan, Paul
- Abstract
Infection with Schistosoma haematobium, the causative agent of urinary schistosomiasis is characterized by high levels of specific immunoglobulin (Ig) E and eosinophilia. The primary cytokines driving production of IgE and eosinophilia are IL-4 and IL-5, respectively. In this study, IL-4 and IL-5 production in children from a schistosome endemic area of Zimbabwe were investigated. Blood samples were taken, stimulated in vitro with either mitogen or schistosome antigens and assayed for IL-4 and IL-5 production. These samples produced either IL-4 or IL-5 but rarely both cytokines when blood was cultured in vitro for 24 or 48 h. After 72 h culture in vitro, both cytokines were detected in most samples. These data imply that while IL-4 and IL-5 are both produced by schistosome infected people, they are not necessarily coproduced.
- Subjects
ZIMBABWE; SCHISTOSOMA haematobium; SCHISTOSOMIASIS treatment; INTERLEUKIN-4; INTERLEUKIN-5; JUVENILE diseases
- Publication
Parasite Immunology, 2000, Vol 22, Issue 7, p341
- ISSN
0141-9838
- Publication type
Article
- DOI
10.1046/j.1365-3024.2000.00311.x