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- Title
The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
- Authors
Wolf, Dieter A.; Chunshui Zhou, Dieter A.; Wee, Susan
- Abstract
The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.
- Subjects
PROTEOLYSIS; PROTEIN metabolism; UBIQUITIN; LIGASES; GENETIC mutation
- Publication
Nature Cell Biology, 2003, Vol 5, Issue 12, p1029
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1203-1029