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- Title
The neuroimaging signal is a linear sum of neurally distinct stimulus- and task-related components.
- Authors
Cardoso, Mariana M B; Sirotin, Yevgeniy B; Lima, Bruss; Glushenkova, Elena; Das, Aniruddha
- Abstract
Neuroimaging (for example, functional magnetic resonance imaging) signals are taken as a uniform proxy for local neural activity. By simultaneously recording electrode and neuroimaging (intrinsic optical imaging) signals in alert, task-engaged macaque visual cortex, we recently observed a large anticipatory trial-related neuroimaging signal that was poorly related to local spiking or field potentials. We used these same techniques to study the interactions of this trial-related signal with stimulus-evoked responses over the full range of stimulus intensities, including total darkness. We found that the two signals could be separated, and added linearly over this full range. The stimulus-evoked component was related linearly to local spiking and, consequently, could be used to obtain precise and reliable estimates of local neural activity. The trial-related signal likely has a distinct neural mechanism, however, and failure to account for it properly could lead to substantial errors when estimating local neural spiking from the neuroimaging signal.
- Subjects
BRAIN imaging; MAGNETIC resonance imaging; NEURAL circuitry; ELECTRODES; ACTION potentials
- Publication
Nature Neuroscience, 2012, Vol 15, Issue 9, p1298
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.3170