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- Title
Selective suppression of hippocampal ripples impairs spatial memory.
- Authors
Girardeau, Gabrielle; Benchenane, Karim; Wiener, Sidney I; Buzsáki, György; Zugaro, Michaël B
- Abstract
Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
- Subjects
HIPPOCAMPUS (Brain); NEOCORTEX; LABORATORY rats; COSMIC ripples; MILD hypertension; CEREBRAL cortex
- Publication
Nature Neuroscience, 2009, Vol 12, Issue 10, p1222
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2384