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- Title
Real-world treatment patterns and clinical outcomes of HCV treatment-naive patients in China: an interim analysis from the CCgenos study.
- Authors
Rao, Hui ‐ ying; Li, Hong; Chen, Hong; Shang, Jia; Xie, Qing; Gao, Zhi ‐ Liang; Li, Jun; Sun, Yongtao; Jiang, Jianning; Wang, Lei; Zhao, Longfeng; Zhang, Lunli; Yang, Weibo; Niu, Junqi; Gong, Zuojiong; Gong, Guozhong; Yang, Ruifeng; Lee, Mei ‐ Hsuan; Wei, Lai
- Abstract
Background and Aim In China, chronic hepatitis C virus (HCV) infection represents a considerable healthcare burden. Although interferon-based therapy has been the standard-of-care for many years, few long-term, real-life studies have assessed interferon-based treatment in China. The objective of CCgenos follow-up study was to analyze long-term treatment patterns and outcomes in a cohort of treatment-naïve, Han ethnic, patients with chronic HCV infection. Methods Patients who had participated in the CCgenos cross-sectional study were invited to enter this 5-year follow up. Clinical information and centralized HCV-RNA measures were collected at scheduled study visits every 6 months for untreated patients and every 3 months for treated patients. Results Among 512 patients enrolled, 334 (65.2%) received interferon-based treatment and 178 (34.8%) remained untreated over a median of 4.1 (1.2-4.3) years. A total of 82.8% (424/512) of patients had an IL28B CC genotype (GT); 60.7% (311/512) had HCV GT1b infection, including 121 (38.9%) untreated. Most patients with baseline cirrhosis were untreated (26/46, 56.5%). Among patients who completed treatment and 24 weeks of post-treatment follow up, the duration of interferon-based therapy was frequently longer than recommended (52.9% [92/174] of GT1b-infected were treated for > 1 year). Rates of sustained virologic response (SVR24) were 71.1% (226/318) overall; 62.4% (111/178) among patients with HCV GT1b infection; and 42.9% (15/35) among patients with cirrhosis. Conclusions There remains a high unmet need for effective HCV treatment in China, evidenced by a high proportion of patients remaining untreated by the current standard-of-care and relatively low SVR24 rates for patients with both GT1b infection and cirrhosis.
- Subjects
HEPATITIS C treatment; HEPATITIS treatment; HEPATITIS C virus; THERAPEUTIC use of interferons; ANTIVIRAL agents
- Publication
Journal of Gastroenterology & Hepatology, 2017, Vol 32, Issue 1, p244
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.13467