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- Title
Prevalence of hepatitis B or C virus infections in patients with non-Hodgkin's lymphoma.
- Authors
Nakamuta,, M; Kuniyoshi, Masami; Nakamuta, Makoto; Sakai, Hironori; Enjoji, Munechika; Kinukawa, Naoko; Kotoh, Kazuhiro; Fukutomi, Marie; Yokota, Masaki; Nishi, Hidehiro; Iwamoto, Hiroaki; Uike, Naokuni; Nishimura, Junji; Inaba, Shuichi; Maeda, Yoshiaki; Nawata, Hajime; Muta, Koichiro
- Abstract
Abstract Background: Hepatitis C virus (HCV) and hepatitis B virus (HBV) are not only hepatotropic, but also lymphotropic viruses. Recently, some reports suggested that these viruses may participate in the development of malignant lymphoproliferative disorders. Methods: We investigated the prevalence of HCV or HBV infection in 348 patients with non-Hodgkin's lymphoma (NHL). We also compared these prevalences with those in blood donors as a control group representing the general population in our area (n = 1 513 358). Next, we evaluated the clinical and pathologic characteristics of HCV- or HBV-infected NHL cases. Non-Hodgkin's lymphoma was classified according to the Working Formulation classification. Results: Thirty-seven cases (14.9%) were found to be infected with HCV or HBV; of these, 20 (8.1%) were infected with HCV, and 17 (6.9%) with HBV. In male NHL patients, the rate of HCV infection was significantly higher than in an age- and sex-matched population in the same area (P < 0.001, Mantel– Haenszel test). The rate of HBV infection also tended to be higher in the population (P = 0.0551). In contrast, in female NHL patients, the rate of HCV or HBV infection was not higher than in the general population. In HCV-infected cases, 15 cases (75%) had B-cell NHL and 16 cases (80%) were classified as being in the intermediate grade; B-cell NHL comprised 83% of all NHL cases. In HBV-infected NHL cases, 11 (65%) were of B-cell type and 10 (58%) were classified as being in the intermediate grade. Conclusions: The high prevalence of HCV or HBV infections in our study population provides epidemiologic evidence suggesting that HCV and HBV infections may be involved in the development of a subgroup of NHL in males. Our investigation also revealed that both HCV- and HBV-infected NHL patients showed certain similarities in clinical and pathologic manifestations.
- Subjects
HEPATITIS viruses; LYMPHOMAS
- Publication
Journal of Gastroenterology & Hepatology, 2001, Vol 16, Issue 2, p215
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.2001.02406.x