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- Title
Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis.
- Authors
Fu, Xiaonan; Han, Yijie; Wu, Ying; Zhu, Xiaoli; Lu, Xin; Mao, Feng; Wang, Xuejing; He, Xuelian; Zhao, Yuhang; Zhao, Yulan
- Abstract
Eur J Clin Invest 2011; 41 (11): 1245-1253 Abstract Background Recent studies have shown that microRNAs (miRNA) could play a potential role as diagnostic and prognostic biomarkers of cancers. The aim of this meta-analysis is to summarize the global predicting role of miR-21 for survival in patients with a variety of carcinomas. Design Eligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall, relapse-free or cancer-specific survival (CSS) in patients with cancer having higher miR-21 expression with those having lower levels. Pooled hazard ratios (HRs) of miR-21 for survival were calculated. Results A total of 17 studies dealing with various carcinomas were included for this global meta-analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR-21 expression in cancerous tissue was 1·69 (95% CI: 1·33-2·16, P < 0·001), which could significantly predict poorer survival in general carcinomas. For relapse-free or CSS, elevated miR-21 was also a significant predictor, with a pooled HR of 1·48 (95% CI: 1·03-2·11, P = 0·033). Importantly, subgroup analysis suggested that higher expression of miR-21 correlated with worse OS in head and neck squamous cell carcinoma (HNSCC) (HR 1·46, 95% CI: 1·13-1·87, P = 0·004) and carcinomas in digestion system (HR 1·56, 95% CI: 1·08-2·26, P = 0·018). Conclusions Our findings suggest that miR-21 detection has a prognostic value in patients with cancer, especially in HNSCC and digestion system cancers.
- Subjects
SQUAMOUS cell carcinoma; BIOMARKERS; PROGNOSTIC tests; SYSTEMATIC reviews; META-analysis; CANCER patients; DIGESTIVE system diseases
- Publication
European Journal of Clinical Investigation, 2011, Vol 41, Issue 11, p1245
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/j.1365-2362.2011.02535.x