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- Title
Propylene Glycol Toxicity in Adolescent with Refractory Myoclonic Status Epilepticus.
- Authors
Bjur, Kara A.; Cannon, Bryan C.; Fine, Anthony L.; Ritter, Matthew J.; Schueler, Kerry E.; Nemergut, Michael E.
- Abstract
Propylene glycol (PG) is a solvent commonly used in medications that, while benign at low doses, may cause toxicity in adults and children at high doses. We describe a case and the physiologic sequelae of propylene glycol toxicity manifested in a critically ill adolescent male with refractory myoclonic status epilepticus aggressively treated with multiple PG-containing medications (lorazepam, phenobarbital, and pentobarbital)—all within accepted dosing guidelines and a total daily PG exposure previously recognized to be safe. Hemodynamic measurements by bedside echocardiography during clinical toxicity are also reported. Clinicians should have a high index of suspicion for propylene glycol toxicity in patients treated with PG-containing medications even when the total PG exposure is lower than currently accepted limits.
- Subjects
PROPYLENE glycols; BENIGN tumors; HEMODYNAMICS; ECHOCARDIOGRAPHY; LORAZEPAM; THERAPEUTICS
- Publication
Case Reports in Pediatrics, 2017, p1
- ISSN
2090-6803
- Publication type
Article
- DOI
10.1155/2017/2979486