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- Title
Use of Nucleolar Organizer Regions in the Histopathological Diagnosis of Colorectal Epithelial Neoplasia.
- Authors
Chida, Tadasu; Ajioka, Yoichi; Watanabe, Hidenobu
- Abstract
The AgNOR technique, specific staining for nucleolar organizer regions, was applied to twenty-seven lesions (sixteen tubular adenomas with low grade atypia and eleven well-differentiated adenocarcinomas invading the submucosa) of colorectal epithelial neoplasia, to examine the possibility of its application to histopathological diagnosis. The mean AgNOR number per adenoma nucleus (2.62±0.16) was significantly higher (P<0.01) than that per carcinoma nucleus (2.28 ± 0.25). The mean cross-sectional area and the maximum diameter of carcinoma AgNORs (1.91 ±0.20 /m2 and 1.89±0.09 /m, respectively) were significantly larger than those of adenoma (1.15±0.17 and 1.45±0.11, respectively). The result of the discriminant analysis using these two variants corresponded to the pathological diagnosis with an accuracy of 96.3% (26/27). We, thus concluded the AgNOR technique to be one of use in the histopathological diagnosis of colorectal epithelial neoplasia.
- Publication
Japanese Journal of Clinical Oncology, 1992, Vol 22, Issue 2, p73
- ISSN
0368-2811
- Publication type
Article