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- Title
Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency.
- Authors
Chan, Samantha; Morgan, Benjamin; Yong, Michelle K.; Margetts, Mai; Farchione, Anthony J.; Lucas, Erin C.; Godsell, Jack; Giang, Nhi Ai; Slade, Charlotte A.; Borstel, Anouk von; Bryant, Vanessa L.; Howson, Lauren J.
- Abstract
The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susceptibility to infections. γδ T cells are a subset of unconventional T cells that play crucial roles in host defence against infections. In this study, we aim to determine the roles and functions of γδ T cells in CVID. We observe a higher frequency of Vδ1 + γδ T cells compared to healthy controls, particularly in older patients. We also find a higher proportion of effectormemory Vδ1 + γδ T cells and a more clonal T cell receptor (TCR) repertoire in CVID. The most significant driver of the Vδ1 + γδ T cell expansion and phenotype in CVID patients is persistent cytomegalovirus (CMV) viremia. These findings provide valuable insights into γδ T cell biology and their contribution to immune defence in CVID.
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-48527-3