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- Title
Ribonucleases P/MRP and the Expanding Ribonucleoprotein World.
- Authors
Hernandez-Cid, Aaron; Aguirre-Sampieri, Sergio; Diaz-Vilchis, Adelaida; Torres-Larios, Alfredo
- Abstract
One of the hallmarks of life is the widespread use of certain essential ribozymes. The ubiquitous ribonuclease P (RNase P) and eukaryotic RNase MRP are essential complexes where a structured, noncoding RNA acts in catalysis. Recent discoveries have elucidated the three-dimensional structure of the ancestral ribonucleoprotein complex, suggested the possibility of a protein-only composition in organelles, and even noted the absence of RNase P in a non-free-living organism. With respect to these last two findings, import mechanisms for RNases P/MRP into mitochondria have been demonstrated, and RNase P is present in organisms with some of the smallest known genomes. Together, these results have led to an ongoing debate regarding the precise definition of how 'essential' these ribozymes truly are. © IUBMB IUBMB Life, 2012.
- Subjects
RIBONUCLEASE P; EUKARYOTIC cells; NUCLEOPROTEINS; ORGANELLES; MITOCHONDRIA; CATALYTIC RNA
- Publication
IUBMB Life, 2012, Vol 64, Issue 6, p521
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.1052