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- Title
Integrated Analysis of the Fecal Metagenome and Metabolome in Bladder Cancer in a Chinese Population.
- Authors
Qin, Chuan; Chen, Zhenghao; Cao, Rui; Shi, Mingjun; Tian, Ye
- Abstract
Bladder cancer (BLCA) is a common malignancy of the urinary system. The gut microbiome produces various metabolites that play functional roles in tumorigenesis and tumor progression. However, the integrative analysis of the gut microbiome and metabolome in BLCA has still been lacking. Thus, the aim of this study was to identify microbial and functional characteristics and metabolites in BLCA in a Chinese population. Metagenomics, targeted metabolomics, bioinformatics, and integrative analysis were used in fecal samples of BLCA patients and healthy individuals. We found gut microbiomes were significantly dysregulated in BLCA patients, including Bifidobacterium, Lactobacillus, Streptococcus, Blautia, and Eubacterium. We also found 11Z-eicosenoic acid, 3-methoxytyrosine, abrine, aniline-2-sulfonate, arachidic acid, conjugated linoleic acids, elaidic acid, glycylleucine, glycylproline, leucyl-glycine, linoelaidic acid, linoleic acid, nicotinamide hypoxanthine dinucleotide, oleic acid, petroselinic acid, and ricinoleic acid to be significantly decreased, while cholesterol sulfate was significantly increased in BLCA patients. Integration of metagenomics and metabolomics revealed interactions between gut microbiota and metabolites and the host. We identified the alterations of gut microbiomes and metabolites in BLCA in a Chinese population. Moreover, we preliminarily revealed the associations between specific gut microbiomes and metabolites. These findings determined potential causative links among gut dysbiosis, dysregulated metabolites, and BLCA.
- Subjects
CHINESE people; FECAL analysis; BLADDER cancer; EICOSANOIC acid; GUT microbiome; MICROBIAL metabolites; NICOTINAMIDE; LINOLEIC acid
- Publication
Genes, 2022, Vol 13, Issue 11, p1967
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes13111967