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- Title
Inverse Association of Plasma Vanadium Concentrations with Gestational Diabetes Mellitus.
- Authors
Li, Xiaoqin; Zhu, Yalun; Yin, Jiawei; Li, Ben; Li, Peiyun; Cao, Benfeng; Wang, Qiang; Xu, Jian; Liu, Liegang
- Abstract
Vanadium compounds were identified to be beneficial for the control of glucose homeostasis. We aimed to explore the association of plasma vanadium (V) with gestational diabetes mellitus (GDM). We performed a case-control study including 252 newly diagnosed GDM cases and 252 controls matched by age, parity, and gestational age. Fasting blood samples were collected from each participant at GDM screening (≥24 weeks of gestation). The plasma concentrations of V were determined utilizing inductively coupled plasma mass spectrometry. Plasma V levels were significantly lower in the GDM group than those in the control group (p < 0.001). The adjusted OR (95% CI) of GDM comparing the highest V tertile with the lowest tertile was 0.35 (0.20–0.61). According to the cubic spline model, the relation between plasma V and odds of GDM was potentially nonlinear (p < 0.001). Moreover, plasma V was negatively correlated with 1-h post-glucose load, 2-h post-glucose load, and lipid metabolism indices (all p < 0.05). The present study indicates an inverse association of plasma V with GDM. Further prospective cohort studies are required to validate our results.
- Subjects
VANADIUM compounds; AGE distribution; CASE-control method; BLOOD sugar; GESTATIONAL age; RISK assessment; MASS spectrometry; PARITY (Obstetrics); DESCRIPTIVE statistics; GESTATIONAL diabetes; ODDS ratio; DISEASE risk factors
- Publication
Nutrients, 2022, Vol 14, Issue 7, p1415
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14071415