We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vitamin E Levels in Ethnic Communities in Malaysia and Its Relation to Glucose Tolerance, Insulin Resistance and Advanced Glycation End Products: A Cross-Sectional Study.
- Authors
Chua, Geoffrey Hong Iing; Phang, Sonia Chew Wen; Wong, Yin Onn; Ho, Loon Shin; Palanisamy, Uma Devi; Abdul Kadir, Khalid
- Abstract
Malaysian national morbidity surveys on diabetic prevalence have shown ethnical variation among prediabetic and diabetic populations. In our attempt to understand this variation, we studied the α-tocopherol, insulin resistance, β-cell function and receptor of advanced glycation end-products (RAGE) levels, as risk factors of type 2 diabetes, among the different ethnicities. In total, 299 subjects of Malay, Chinese, Indian and aboriginal Orang Asli (OA) heritage were recruited from urban and rural areas of Malaysia by stratified random sampling. Serum α-tocopherol concentrations were measured using high performance liquid chromatography (HPLC) and insulin concentrations were measured using enzyme-linked immunosorbent assay (ELISA). In subjects with pre-diabetes, OAs had the highest α-tocopherol level, followed by Chinese and Malays (0.8938, 0.8564 and 0.6948 respectively; p < 0.05). In diabetic subjects, Malays had significantly higher RAGE levels compared to Chinese and Indians (5579.31, 3473.40 and 3279.52 pg/mL respectively, p = 0.001). Low α-tocopherol level (OR = 3.021, p < 0.05) and high insulin resistance (OR = 2.423, p < 0.05) were linked strongly to the development of pre-diabetes. Low β-cell function (OR = 5.657, p < 0.001) and high RAGE level (OR = 3.244, p < 0.05) were linked strongly to the development of diabetes from pre-diabetes. These factors might be involved in the development of diabetes, along with genetic and environmental factors.
- Subjects
MALAYSIA; GENETICS of diabetes; DIABETES risk factors; CELL receptors; STATISTICAL correlation; DIABETES; DISEASES; ECOLOGY; ENZYME-linked immunosorbent assay; ETHNIC groups; HIGH performance liquid chromatography; INSULIN resistance; ISLANDS of Langerhans; PREDIABETIC state; VITAMIN E; DISEASE prevalence; CROSS-sectional method; GLUCOSE intolerance; ADVANCED glycation end-products; ODDS ratio
- Publication
Nutrients, 2020, Vol 12, Issue 12, p3659
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12123659