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- Title
Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress.
- Authors
Diz-Chaves, Yolanda; Herrera-Pérez, Salvador; González-Matías, Lucas C.; Lamas, José Antonio; Mallo, Federico
- Abstract
Glucagon like-peptide 1 (GLP-1) within the brain is produced by a population of preproglucagon neurons located in the caudal nucleus of the solitary tract. These neurons project to the hypothalamus and another forebrain, hindbrain, and mesolimbic brain areas control the autonomic function, feeding, and the motivation to feed or regulate the stress response and the hypothalamic-pituitary-adrenal axis. GLP-1 receptor (GLP-1R) controls both food intake and feeding behavior (hunger-driven feeding, the hedonic value of food, and food motivation). The activation of GLP-1 receptors involves second messenger pathways and ionic events in the autonomic nervous system, which are very relevant to explain the essential central actions of GLP-1 as neuromodulator coordinating food intake in response to a physiological and stress-related stimulus to maintain homeostasis. Alterations in GLP-1 signaling associated with obesity or chronic stress induce the dysregulation of eating behavior. This review summarized the experimental shreds of evidence from studies using GLP-1R agonists to describe the neural and endocrine integration of stress responses and feeding behavior.
- Subjects
HYPOTHALAMUS physiology; SYMPATHETIC nervous system physiology; ENDOCRINE gland physiology; CELLULAR signal transduction; FOOD habits; HOMEOSTASIS; INGESTION; MEMBRANE proteins; NEUROTRANSMITTERS; PSYCHOLOGICAL stress; GLUCAGON-like peptide 1
- Publication
Nutrients, 2020, Vol 12, Issue 11, p3304
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12113304