We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Alginate Films Containing Viable Lactobacillus Plantarum: Preparation and In Vitro Evaluation.
- Authors
Brachkova, Mariya; Duarte, Aida; Pinto, João
- Abstract
The objective of the study was to develop calcium alginate films, containing Lactobacillus plantarum ATCC 8040 with preserved and stable viability and antibacterial activity. L. plantarum-loaded films containing different calcium concentrations were physically characterized for mechanical and bioadhesive properties and lactobacilli release. The viability and antibacterial activity of L. plantarum was studied before and after processing, and during 6 months of storage. A multiresistant clinical isolate, VIM-2-metalo-β-lactamase producing Pseudomonas aeruginosa, was used as an indicator strain. Interference between L. plantarum and films enhanced films elasticity, water absorption ability, release of lactobacilli, and decreased films adherence. A decrease of L. plantarum viability in alginate films (≤1 log unit) was observed after freeze drying. L. plantarum, at cell concentrations of 10 cfu/ml, was inhibitory active. The viability and antibacterial activity of the immobilized lactobacilli remained stable during 6 months of storage. The study has proved the potential of alginate films to deliver L. plantarum in high numbers to individuals.
- Publication
AAPS PharmSciTech, 2012, Vol 13, Issue 2, p357
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-012-9753-z