We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Steering the multipotent mesenchymal cells towards an anti-inflammatory and osteogenic bias via photobiomodulation therapy: How to kill two birds with one stone.
- Authors
Amaroli, Andrea; Pasquale, Claudio; Zekiy, Angelina; Benedicenti, Stefano; Marchegiani, Andrea; Sabbieti, Maria Giovanna; Agas, Dimitrios
- Abstract
The bone marrow-derived multipotent mesenchymal cells (MSCs) have captured scientific interest due to their multipurpose features and clinical applications. The operational dimension of MSCs is not limited to the bone marrow reservoir, which exerts bone-building and niche anabolic tasks; they also meet the needs of quenching inflammation and restoring inflamed tissues. Thus, the range of MSC activities extends to conditions such as neurodegenerative diseases, immune disorders and various forms of osteopenia. Steering these cells towards becoming an effective therapeutic tool has become mandatory. Many laboratories have employed distinct strategies to improve the plasticity and secretome of MSCs. We aimed to present how photobiomodulation therapy (PBM-t) can manipulate MSCs to render them an extraordinary anti-inflammatory and osteogenic instrument. Moreover, we discuss the outcomes of different PBM-t protocols on MSCs, concluding with some perplexities and complexities of PBM-t in vivo but encouraging and feasible in vitro solutions.
- Subjects
PHOTOBIOMODULATION therapy; BONE marrow; IMMUNOLOGIC diseases; BONE regeneration; BONE marrow cells; CLINICAL medicine
- Publication
Journal of Tissue Engineering, 2022, Vol 13, p1
- ISSN
2041-7314
- Publication type
Article
- DOI
10.1177/20417314221110192