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- Title
No effect on behavior in a pilot study investigating the role of progesterone in nicotine withdrawal in female rats.
- Authors
Fall, Kiana L.; Forbes-Lorman, Robin M.
- Abstract
Tobacco use and nicotine addiction are leading causes of preventable death and disease. While nicotine addiction is a problem in both males and females, females are more vulnerable to addiction, intense withdrawal symptoms, and relapse. This vulnerability is attributed in part to ovarian hormones estrogen and progesterone, which cycle dynamically throughout the female menstrual cycle. This study used a novel paradigm to examine the effects of progesterone treatment on behavioral withdrawal symptoms following the establishment of nicotine dependence via drinking water in 22 ovariectomized female rats. We predicted that rats treated with progesterone would exhibit less severe nicotine withdrawal symptoms than the control rats. We were unable to determine the role of progesterone in nicotine withdrawal as nicotine dependence was not established; however, this topic is relevant for future clinical use in treating nicotine withdrawal symptoms, particularly in females. By investigating the role of progesterone in female smokers, more effective treatments can be developed to mitigate withdrawal symptoms upon nicotine cessation and accommodate females struggling with addiction.
- Subjects
MENSTRUAL cycle; NICOTINE; PROGESTERONE receptors; PROGESTERONE; TERMINATION of treatment; NICOTINE addiction; DRUG withdrawal symptoms
- Publication
Bios, 2024, Vol 92, Issue 2, p104
- ISSN
0005-3155
- Publication type
Article
- DOI
10.1893/BIOS-D-23-00007