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- Title
Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel—Reply.
- Authors
Shavit, Itai; Koppel, Jordanna H.; Levy, Nitai
- Abstract
Several recent studies support vaccine effectiveness against MIS-C. Holm et al[2] and Nygaard et al[3] reported that the risk of MIS-C during the Omicron wave in Denmark was significantly lower in vaccinated compared with unvaccinated children and adolescents. Comment & Response B In Reply b We appreciate the comments by Dr Jiang and colleagues regarding our recent Research Letter.[1] In our cohort, 5 of 79 patients (6.3%) during the Delta wave and 5 of 33 patients (15.1%) during the Omicron wave received a second dose of the SARS-CoV-2 vaccine at least 2 weeks prior to hospital admission; none of the vaccinated patients were admitted to intensive care units or required treatment with vasopressors.[1] The incidence rate of MIS-C during the Omicron wave was lower than during both the Delta and Alpha waves.[1] Jiang and colleagues state that receipt of 2 doses of SARS-CoV-2 vaccine "was associated with a lower incidence and more favorable outcomes of MIS-C." Incidence and clinical phenotype of multisystem inflammatory syndrome in children after infection with the SARS-CoV-2 Delta variant by vaccination status: a Danish nationwide prospective cohort study.
- Publication
JAMA: Journal of the American Medical Association, 2022, Vol 328, Issue 15, p1562
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2022.15220