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- Title
Supramolecular Assembly Models of siRNA Delivery Systems.
- Authors
Sun, Jing; Wang, Jiancheng; Yang, Zhenjun
- Abstract
Small interfering RNA (siRNA) technology, which could be able to silence specific targeted mRNAs rapidly and efficiently, has been regarded as a novel and potent gene therapeutic approach for diseases, such as cancers, infections, inflammations and neurological disorders. However, some conspicuous intrinsic defects of siRNA including the poor cellular uptake, low biological stability, unfavorable pharmacokinetics and bio-distribution properties, have hindered further applications in clinic. Therefore, it is prerequisite to design safe and effective siRNA delivery systems for the successful development of siRNA-based various diseases therapeutics. This review aims to analyze and summarize these supramolecular assembly models in the process of siRNA delivery, namely recent nanotechnological strategies for carrying siRNA by using diverse non-viral vehicles such as cationic liposomes, stable nucleic acid lipid particles (SNALPs), cationic polymers, cationic dendrimers, inorganic nanoparticles and others. Eventually, it is concluded with future perspectives of siRNA therapeutics in the field of non-viral carriers.
- Subjects
SMALL interfering RNA; GENE silencing; NUCLEIC acids; INORGANIC chemistry; NANOPARTICLES; GENE therapy
- Publication
Chinese Journal of Chemistry, 2015, Vol 33, Issue 1, p79
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.201400484