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- Title
Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal.
- Authors
Lo, Anthony T. S.; Salam, Noeris K.; Hibbs, David E.; Rutledge, Peter J.; Todd, Matthew H.
- Abstract
Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.
- Subjects
BIOCHEMISTRY; CYCLAMEN; PYRROLES; ZINC; COPPER; LIGAND binding (Biochemistry); DNA; ISOTHERMAL titration calorimetry
- Publication
PLoS ONE, 2011, Vol 6, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0017446