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- Title
Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration.
- Abstract
The article offers information on the study conducted by the authors related to idebenone, which increases mitochondrial complex I activity in fibroblasts from leber's hereditary optic neuropathy (LHON) patients while producing contradictory effects on respiration. It states that LHON is caused by mutations in the complex I subunits of the respiratory chain. It mentions that the study concluded that idebenone is able to compensate the complex I deficiency in LHON patient cells with variable effects on respiration, indicating that the patients might not be equally likely to benefit from the treatment.
- Publication
BMC Research Notes, 2011, Vol 4, Issue 1, p557
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/1756-0500-4-557