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- Title
Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines.
- Authors
Revanasiddappa, B. C.; Rao, R. Nagendra; Subrahmanyam, E. V. S.; Satyanarayana, D.
- Abstract
A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR, 1H NMR, and Mass spectral data. All the final compounds were evaluated for their in vitro antimicrobial activity.
- Subjects
HETEROCYCLIC compounds; CONDENSATION; ALDEHYDES; ACETOPHENONE; RING formation (Chemistry); ISONIAZID; ACETIC acid; MELTING points; ANTI-infective agents; STREPTOMYCIN
- Publication
E-Journal of Chemistry, 2010, Vol 7, Issue 1, p295
- ISSN
0973-4945
- Publication type
Article
- DOI
10.1155/2010/415723