We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antioxidant and Antithrombotic Therapies for Diabetic Kidney Disease.
- Authors
Wenjun Yan; Baoqin Zhou; Yunfeng Shen; Gaosi Xu
- Abstract
With an increasing incidence, diabetic kidney disease (DKD) has been the leading cause of chronic kidney disease and end-stage renal disease, and conventional therapies did not change this situation. This study intended to review and analyze the antioxidant and antithrombotic treatments of DKD for seeking novel therapeutic strategies. Relevant articles involved with antioxidant and antithrombotic treatments in DKD were retrieved and analyzed via systematic assessment. Meta-analysis showed that pancreatic kallikrein definitely reduced glycated hemoglobin in DKD patients (mean difference, 0.36%; 95% confidence interval, 0.08% to 0.63%; P = .01). Apart from the classic agents such as aspirin, novel drugs such as pancreatic kallikrein, sulodexide, and especially the traditional Chinese medicine including Tripterygium wilfordii and lumbrukinase, exert beneficial effects in DKD patients. Antioxidant and antithrombotic treatments are beneficial for DKD patients and represent promising therapeutic strategies in the future.
- Subjects
DIABETIC nephropathies; KIDNEY disease risk factors; THERAPEUTIC use of antioxidants; FIBRINOLYTIC agents; GLYCOSYLATED hemoglobin
- Publication
Iranian Journal of Kidney Diseases, 2015, Vol 9, Issue 6, p413
- ISSN
1735-8582
- Publication type
Article